FOS
LOCUS ID2353
GENE_SYMBOLFOS
GENE NAMEFBJ murine osteosarcoma viral oncogene homolog
SYNONYMNSp55, AP-1, C-FOS
CHROMOSOME14
HOMOLOGENE ID3844
microRNAsNANA
GENE SUMMARY
The Fos gene family consists of 4 membersFOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Increased intracellular ROS generation in PBMCs of diabetic patients is involved in the pathogenesis of diabetic nephropathy via activation NF-kappaB and AP-1 and an increased expression of TGF-beta1.18485515