FTO
LOCUS ID79068
GENE_SYMBOLFTO
GENE NAMEfat mass and obesity associated
SYNONYMNSALKBH9
CHROMOSOME16
HOMOLOGENE ID8053
microRNAsNANA
GENE SUMMARY
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated D and R damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with diabetic nephropathy23298195
Cardiovascular1. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with cardiovascular risk.23298195