FTO
LOCUS ID79068
GENE_SYMBOLFTO
GENE NAMEfat mass and obesity
SYNONYMNSALKBH9
CHROMOSOME16
HOMOLOGENE ID8053
microRNAsNANA
GENE SUMMARY
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated D and R damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with diabetic nephropathy23298195
Cardiovascular1. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with cardiovascular risk.23298195
Retinopathy1. After stratification of patients according to the presence/absence of vascular complications, we found significant associations of variants in the CAT, FTO, and UCP1 genes with diabetic retinopathy and nephropathy.29410390
Insulin resistance and Inflammation1. Results of our study showed a significant association of?FTO?genetic variant rs8050136 A>C with the major markers of insulin resistance, obesity and inflammation, opening new avenues for solving many unclear questions in the pathogenesis of T2D.30867643