GENE NAMEgamma-glutamyltransferase 1
SYNONYMNSGGT, GTG, CD224, GGT, 1, D22S672, D22S732
The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]


Complication Evidence PMID
Nephropathy1. Urinary GGT and ALP have potential value in the diagnosis of nephropathy in type 2 diabetic patients, but GGT has a slightly higher ability to discrimite nephropathy than ALP.21527256
Cardiovascular1. Higher GGT levels are a risk factor for all-cause and cardiovascular disease death in people with and without diabetes.22796154
Retinopathy1. We herein describe for the first time the significant interactive effects of the GGT1 G allele and a low HDL-C level on a high baPWV and DR.25952030
Neuropathy1. The measurement of serum GGT and Hcy in addition to HbA1c and disease duration could facilitate the early detection of neuropathy in diabetic patients.22315139