HDAC4
LOCUS ID9759
GENE_SYMBOLHDAC4
GENE NAMEhistone deacetylase 4
SYNONYMNSHD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A
CHROMOSOME2
HOMOLOGENE ID55946
microRNAsNANA
GENE SUMMARY
Thus, HDAC4 contributes to podocyte injury and is one of critical components of a signal transduction pathway that links renal injury to autophagy in diabetic nephropathy.

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. hyperglycemia impairsMiRNA-29a signaling to intensify HDAC4 actions that contribute to podocyte protein deacetylation and degradation as well as renal dysfunction. HDAC4, via epigenetic H3K9 hypoacetylation, reducesMiRNA-29a transcription. The renoprotective effects ofMiRNA-29a in diabetes-induced loss of podocyte integrity and renal homeostasis highlights the importance of post-translational acetylation reactions in podocyte microenvironments. IncreasingMiRNA-29a action may protect against diabetic podocytopathy.24717296