| HMOX1 |
| LOCUS ID | 3162 | ||||||||||||||||
| GENE_SYMBOL | HMOX1 | ||||||||||||||||
| GENE NAME | heme oxygenase 1 | ||||||||||||||||
| SYNONYMNS | HO-1, HSP32, HMOX1D, bK286B10 | ||||||||||||||||
| CHROMOSOME | 22 | ||||||||||||||||
| HOMOLOGENE ID | 31075 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The findings of this study indicate that increases of urine HO-1 levels can be detected in patients with type 2 diabetes before the onset of significant albuminuria, and associated with renal derangement in patients with established diabetic nephropathy. | 26733347 |
| Tuberculosis | 1. Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity. | 24458266 |
| Neuropathy | 1. In this study, CTGF, HO-1 and NT-3 were highly correlated with type 2 diabetic peripheral neuropathy. The conduction velocity of nerve increased with the increase of CTGF, HO-1 and NT-3. Immune cytokine TGF-?1 combined with cattle encephalon glycoside and ignotin injection could improve the contents of CTGF, HO-1 and NT-3, and be better to treat the peripheral neuropathy of type 2 diabetes. | 29259937 |