HSPA1B
LOCUS ID3304
GENE_SYMBOLHSPA1B
GENE NAMEheat shock 70kDa protein 1B
SYNONYMNSHSP70-2, HSP70.2, HSP70-1B
CHROMOSOME6
HOMOLOGENE ID74294
microRNAsNANA
GENE SUMMARY
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element R-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. results indicate that the HSP70-1 and HSP70-2 polymorphisms are associated with renal complications in T2DM and may be useful in identifying patients with increased risk of DN.18518860