IGFBP1
LOCUS ID3484
GENE_SYMBOLIGFBP1
GENE NAMEinsulin like growth factor binding protein 1
SYNONYMNSAFBP, IBP1, PP12, IGF-BP25, hIGFBP-1
CHROMOSOME7
HOMOLOGENE ID498
microRNAsNANA
GENE SUMMARY
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The first genomic markers to be associated with diabetic microvascular complications within the human IGFBP1 gene.16306374