IGFBP3
LOCUS ID3486
GENE_SYMBOLIGFBP3
GENE NAMEinsulin-like growth factor binding protein 3
SYNONYMNSIBP3, BP-53
CHROMOSOME7
HOMOLOGENE ID510
microRNAsNANA
GENE SUMMARY
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a terry complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alterte transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Insulin-like growth factor (IGF) and the insulin-like growth factor-binding protein-3 (IGFBP3) system are known to be involved in the development of experimental diabetic nephropathy, and Urinary IGFBP3 protease activity has been observed in patients with type 2 diabetes.22014109