IGFBP7
LOCUS ID3490
GENE_SYMBOLIGFBP7
GENE NAMEinsulin like growth factor binding protein 7
SYNONYMNSAGM,PSF,TAF,FSTL2,IBP-7,MAC25,IGFBP-7,RAMSVPS,IGFBP-7v,IGFBPRP1
CHROMOSOME4
HOMOLOGENE ID1193
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

OBSERVATIONS

Complication Evidence PMID
NephropathyTGF-beta1 enhances IGFBP7 via Smad2/4 pathways, and that IGFBP7 might be involved in the TGF-beta 1-induced tubular injury in DN26974954