IL17A
LOCUS ID3605
GENE_SYMBOLIL17A
GENE NAMEinterleukin 17A
SYNONYMNSIL17, CTLA8, IL-17, CTLA-8, IL-17A
CHROMOSOME6
HOMOLOGENE ID1651
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. We observed that IL-17A levels in plasma and urine were reduced in patients with advanced diabetic nephropathy.26334030
Retinopathy1. Serum IL-6 and IL-17 were inversely associated with T2DM retinopathy.24632587
Tuberculosis1. We also found that TB-DM is characterized by expanded frequencies of TB antigen-stimulated NK cells expressing type 1 (tumour necrosis factor-?) and type 17 (IL-17A and IL-17F) cytokines25363329