IL1RN
LOCUS ID3557
GENE_SYMBOLIL1RN
GENE NAMEinterleukin 1 receptor antagonist
SYNONYMNSDIRA, IRAP, IL1F3, IL1RA, MVCD4, IL-1RN, IL-1ra, I
CHROMOSOME2
HOMOLOGENE ID11163
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Altertive splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. IL1B2 and IL1RN*2 genotypes of the IL-1 cluster genes are associated with diabetic nephropathy in Korean patients with type 2 DM.15286433