KL
LOCUS ID9365
GENE_SYMBOLKL
GENE NAMEklotho
SYNONYMNSNA
CHROMOSOME13
HOMOLOGENE ID68415
microRNAsmiR-199b-5p26813039
GENE SUMMARY
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1.The increased serum klotho, mediated byMiRNA-199b-5p, is a possible mechanism by which atrasentan prevents renal tubular injury in DN. 2. Regarding to the (GT)n repeats, the LL genotype showed a higher odds ratio for the development of albuminuria only in patients with hypertension when compared to the S allele.In conclusion, the T(-413)A SNP in the HO-1 promoter is significantly associated with albuminuria development in type 2 diabetes patients, especially with longer duration and poor glycemic control.26813039, 26512580