LEP
LOCUS ID3952
GENE_SYMBOLLEP
GENE NAMEleptin
SYNONYMNSOB, OBS, LEPD
CHROMOSOME7
HOMOLOGENE ID193
microRNAsmiR-199a-3p27279151
GENE SUMMARY
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Atherosclerosis1. Studies in cells and animal models support that leptin has a pro-atherogenic potential and exerts pro-hypertrophic effects on the heart.26126055
Neuropathy1. The leptin-deficient ob/ob mouse is a new animal model that develops both large motor and sensory fiber and small sensory fiber peripheral diabetic neuropathy (PDN).17130477
Nephropathy1. The ZDSD rat is a new obese-diabetic rat model that expresses type 2 diabetes in the presence of an intact leptin pathway,results position the ZDSD rat as a relevant model of diabetic nephropathy that can be treated with clinically effective compounds.28979697
Cardiovascular1. CONCLUSIONS: These results indicate that canagliflozin may improve adipose tissue function and induce changes in serum leptin, adiponectin, and IL-6 that favorably impact insulin sensitivity and cardiovascular disease risk.28967613