MAPK14
LOCUS ID1432
GENE_SYMBOLMAPK14
GENE NAMEmitogen-activated protein kinase 14
SYNONYMNSRK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRK
CHROMOSOME6
HOMOLOGENE ID31777
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical sigls, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four altertively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Glomerular p38 MAPK activity was increased in early DN. This activated p38 MAPK pathway in diabetic glomeruli may, in part, play a role in the pathogenesis of early hypertrophy and extracellular matrix accumulation.11473637