MMP24
LOCUS ID9518
GENE_SYMBOLMMP24
GENE NAMEMatrix Metallopeptidase 24
SYNONYMNSMMP25, MMP-24, MT5MMP, MTMMP5, MT-MMP5, MT5-MMP, MT-MMP 5
CHROMOSOME20
HOMOLOGENE ID21331
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the peptidase M10 family of matrix metalloproteises (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagese). [provided by RefSeq, Feb 2016]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Because renal tubular atrophy is a significant factor in the pathogenesis of diabetic nephropathy and renal failure and the molecular mechanisms regulating this process remain unknown, it is hypothesized that the elevated expression of MT5-MMP contributes to the activation of pro-MMP-2, which participates in the remodeling of the proximal and distal tubules as well as in the collecting duct.These provide the first evidence of the expression of a MT-MMP in diabetes and suggest a novel role for MT5-MMP in the pathogenesis of renal tubular atrophy and end-stage renal disease.11457723