NOS2
LOCUS ID4843
GENE_SYMBOLNOS2
GENE NAMEnitric oxide synthase 2
SYNONYMNSNOS, INOS, NOS2A, HEP-NOS
CHROMOSOME17
HOMOLOGENE ID55473
microRNAsNANA
GENE SUMMARY
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1.Studies have reported that (CCTTT)n repeat in the promoter region of NOS2A gene was significantly associated with the absence of diabetic retinopathy.[22] Therefore, NOS2A is considered a candidate gene in diabetic retinopathy.12090088
Nephropathy1. These preliminary findings indicate that the NOS2 rs2779248, NOS2 rs1137933, and NOS3 rs3918188 genetic polymorphisms are potentially related to the susceptibility to T2DM, and the rs1800783 polymorphism might be considered as genetic risk factors for diabetic nephropathy, and family history of diabetes was closely associated with rs11771443 polymorphism in DN, and the genetic variants might be used as molecular markers for evaluating the risk of T2DM and diabetic nephropathy27192959