GENE NAMEneuropeptide Y
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes including cortical excitability stress response food intake circadian rhythms and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase activate mitogen-activated protein kinase (MAPK) regulate intracellular calcium levels and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels higher alcohol consumption and may be a risk factor for various metabolic and cardiovascular diseases. [provided by RefSeq Nov 2009]


Complication Evidence PMID
Nephropathy1. The present study has, for the first time, shown high plasma IR-NPY concentrations and Urinary IR-NPY excretion in NIDDM patients with advanced nephropathy.10426578
Retinopathy1. NPY and Y2-receptor play important roles in diabetic retinopathy and retinal neovascularization and are thus potential new targets for drug molecules for treatment of retinopathy.15181979
Atherosclerosis1. The indicate significant associations between inflammatory cell activation in blood and vascular atherosclerosis in genetically prone subjects, and provide possible mechanistic information about the role of NPY and the Leu7Pro polymorphism in the development of atherosclerosis.21746772
Neuropathy1. These demonstrate that the expression of neuropeptides and their receptors in the diabetic heart is significantly impaired, and may be the link between neuropathy and cardiac complications. Further studies are warranted to delineate pathophysiologic mechanisms associated with dysregulation of the cardiac neuropeptide system and the relationship to cardiac complications in diabetes.22029806