PDGFA
LOCUS ID5154
GENE_SYMBOLPDGFA
GENE NAMEplatelet-derived growth factor alpha polypeptide
SYNONYMNSPDGF1, PDGF-A
CHROMOSOME7
HOMOLOGENE ID32055
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or altertively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Furthermore, an increased expression of PDGF-A has also been observed in the course of human diabetic nephropathy.15517944