PDGFB
LOCUS ID5155
GENE_SYMBOLPDGFB
GENE NAMEplatelet-derived growth factor beta polypeptide
SYNONYMNSSIS, SSV, IBGC5, PDGF2, c-sis, PDGF-2
CHROMOSOME22
HOMOLOGENE ID74303
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or altertively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. In contrast, the percentages of PDGF-B and PDGFR-Beta mR-positive cells in DN were significantly higher than those in NHK, and were significantly higher in DN I than in DN IIThe percentages of cells positive for PDGF-B correlated with the PDGFR-Beta mRNA level.15067514