| PDPK1 |
| LOCUS ID | 5170 | ||||||||||
| GENE_SYMBOL | PDPK1 | ||||||||||
| GENE NAME | 3-phosphoinositide d | ||||||||||
| SYNONYMNS | PDK1, PDPK2, PDPK2P, PRO0461 | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 37643 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| PDPK1 (3-Phosphoinositide Dependent Protein Kinase 1) is a Protein Coding gene. Diseases associated with PDPK1 include Endometrial Cancer and Esophageal Adenosquamous Carcinoma. Among its related pathways are Development_Leptin signaling via PI3K-dependent pathway and Development HGF signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Interestingly, PDK1 was downregulated in the glomeruli of diabetic rats and patients with type 2 diabetes before the onset of proteinuria, further suggesting that reduced expression of PDK1 associates with podocyte injury and development of DN. | 25950482 |