PICK1
LOCUS ID9463
GENE_SYMBOLPICK1
GENE NAMEprotein interacting with PRKCA 1
SYNONYMNSPICK, PRKCABP
CHROMOSOME22
HOMOLOGENE ID7470
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. we have provided a molecular model of hyperglycemia-induced nephrin endocytosis and subsequent proteinuria and highlighted PKCalpha and PICK1 as promising therapeutic targets for diabetic nephropathy.18752002