| PICK1 |
| LOCUS ID | 9463 | ||||||||||
| GENE_SYMBOL | PICK1 | ||||||||||
| GENE NAME | protein interacting | ||||||||||
| SYNONYMNS | PICK, PRKCABP | ||||||||||
| CHROMOSOME | 22 | ||||||||||
| HOMOLOGENE ID | 7470 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. we have provided a molecular model of hyperglycemia-induced nephrin endocytosis and subsequent proteinuria and highlighted PKCalpha and PICK1 as promising therapeutic targets for diabetic nephropathy. | 18752002 |