PIK3CA
LOCUS ID5290
GENE_SYMBOLPIK3CA
GENE NAMEphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
SYNONYMNSMCM, CWS5, MCAP, PI3K, CLOVE, MCMTC, p110-alpha
CHROMOSOME3
HOMOLOGENE ID21249
microRNAsNANA
GENE SUMMARY
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Activation of the PI3K/AKT/mTOR pathway is a crucial molecular event in human clear cell renal cell carcinoma (ccRCC), and is also upregulated in diabetic nephropathy.25948777