PPIA
LOCUS ID5478
GENE_SYMBOLPPIA
GENE NAMEpeptidylprolyl isomerase A
SYNONYMNSCYPA,CYPH,HEL-S-69p
CHROMOSOME7
HOMOLOGENE ID134504
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. The SNP rs6850: A?>?G is associated with increased risk for elevated plasma levels of cyclophilin A and coronary artery disease in patients with and without type 2 diabetes.26702934
Nephropathy1. Urinary CypA is a good biomarker for early DN detection in humans and it can be released from either mesangial or tubular cells.26496315