| RELA |
| LOCUS ID | 5970 | |||||||||||||
| GENE_SYMBOL | RELA | |||||||||||||
| GENE NAME | v-rel avian reticuloendotheliosis viral oncogene homolog A | |||||||||||||
| SYNONYMNS | p65, NFKB3 | |||||||||||||
| CHROMOSOME | 11 | |||||||||||||
| HOMOLOGENE ID | 32064 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Nuclear NF-kappa B p65 in peripheral blood mononuclear cells correlates with urinary MCP-1, RANTES and the severity of type 2 diabetic nephropathy. | 24936866 |
| Retinopathy | 1. The present data suggest that hyperglycemia increases O-GlcNAcylation in DR and that O-GlcNAcylation of the p65 subunit of NF-KappaB is involved in hyperglycemia-induced NF-KappaB activation and RGC death in DR. | 25835259 |