SAA@
LOCUS ID6287
GENE_SYMBOLSAA@
GENE NAMEserum amyloid A1 cluster
SYNONYMNSSAA, SAA4
CHROMOSOME11
HOMOLOGENE IDNA
microRNAsNANA
GENE SUMMARY
NA

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. SAA was increased in type 2 diabetic patients with incipient or overt nephropathy and SAA was associated with impairment of SR-BI-mediated cholesterol efflux to serum. SAA was significantly increased in diabetic patients with incipient or overt nephropathy.24267259
Cardiovascular1. In patients with low SAA, higher HDL-C was associated with lower all-cause and cardiovascular mortality. 2. The association of HDL with SAA leads to a change in its protein and lipid composition, and potentially causes the HDL molecule to become dysfunctional, losing several protective properties, thus promoting the development of CVD?.26248570, 28596970
Retinopathy1. Conditional logistic regression on matched paired data revealed that subjects in the top quartile for sTNFR-I (OR = 2.13), sTNFR-II (OR = 1.66), sgp130 (OR = 1.82), sIL6R (OR = 1.75), sVCAM1 (OR = 1.98), sICAM1 (OR = 2.23), CRP (OR = 2.40) and SAA (OR = 2.03), had the highest odds of having DR.26339132