SERPINF1
LOCUS ID5176
GENE_SYMBOLSERPINF1
GENE NAMEserpin family F member 1
SYNONYMNSOI6, OI12, PEDF, EPC-1, PIG35
CHROMOSOME17
HOMOLOGENE ID1965
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. PEDF fragment (P78-PEDF) confers kidney protection in diabetic nephropathy (DN). Continuous infusion of P78-PEDF for 6 wk resulted in protection from diabetic neuropathy as indicated by reduced albuminuria and blood urea nitrogen, increased nephrin expression, decreased kidney macrophage recruitment and inflammatory cytokines, and reduced histological changes compared with vehicle-treated diabetic mice.23884140
Retinopathy1. The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]20141354
Neuropathy1. Continuous infusion of P78-PEDF for 6 wk resulted in protection from diabetic neuropathy as indicated by reduced albuminuria and blood urea nitrogen, increased nephrin expression, decreased kidney macrophage recruitment and inflammatory cytokines, and reduced histological changes compared with vehicle-treated diabetic mice.23884140