SIRT1
LOCUS ID23411
GENE_SYMBOLSIRT1
GENE NAMEsirtuin 1
SYNONYMNSSIR2L1
CHROMOSOME10
HOMOLOGENE ID56556
microRNAsmiR-181a,MiRNA-34a,mir-9,miRNA22476949 , 23834033, 21288303,
GENE SUMMARY
This gene encodes a member of the sirtuin family of proteins homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombition of rD. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Altertive splicing results in multiple transcript variants. [provided by RefSeq Dec 2008]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. The present findings reveal that diabetes-induced retinal inflammation stems from downregulation of the AMP-activated protein kinase (AMPK) pathway, leading subsequently to SIRT1 deactivation and NF-KB activation. The data also suggest the potential use of the AMPK activator resveratrol as a therapeutic agent for diabetic retinopathy.22058332
Cardiovascular1. SIRT1 therefore has a critical role and holds exciting prospects for new therapeutic strategies that can offer reparative processes for cardiac, vascular, and nervous system degenerative disorders as well as targeted control of aberrant cell growth during cancer.25815111
Atherosclerosis1. Decreased expression of SIRT1 in artery may be involved in the initiation and development of diabetic atherosclerosis21810449
Nephropathy1. SIRT1 rs10823108 and FOXO1 rs17446614 are responsible for genetic susceptibility to diabetic nephropathy.28860538
Dyslipidemia1. SIRT1 has been suggested as putative therapeutic target in multiple age-related diseases including type 2 diabetes and dyslipidemias.23284689