SLC30A10
LOCUS ID55532
GENE_SYMBOLSLC30A10
GENE NAMEsolute carrier family 30 member 10
SYNONYMNSZNT8, ZRC1, HMDPC, ZNT10, ZnT-10
CHROMOSOME1
HOMOLOGENE ID100946
microRNAsNANA
GENE SUMMARY
This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Altertively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. These suggest that GADA and anti-ZnT8 are associated with progression of serious T2D complications, including polyneuropathy and nephropathy. In addition, adiposity represents a significant risk for autoimmunity development in T2D patients.25611374