SRGN
LOCUS ID5552
GENE_SYMBOLSRGN
GENE NAMEserglycin
SYNONYMNSPPG, PRG, PRG1
CHROMOSOME10
HOMOLOGENE ID2043
microRNAsNANA
GENE SUMMARY
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. The few available studies show that higher PPG is associated with increased all-cause and cardiovascular death, incidence of major cardiovascular events (including myocardial infarction and stroke), and progression of diabetic retinopathy.22116350