STK11
LOCUS ID6794
GENE_SYMBOLSTK11
GENE NAMEserine/threonine kinase 11
SYNONYMNSPJS, LKB1, hLKB1
CHROMOSOME19
HOMOLOGENE ID393
microRNAsNANA
GENE SUMMARY
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal domint disorder characterized by the growth of polyps in the gastrointestil tract, pigmented macules on the skin and mouth, and other neoplasms. Alterte transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Our results give further insights into the mechanisms underlying the protective role of fenofibrate in DN via modulation of AMPK, LKB1 and eNOS mRNA expression.25967095