SUMO4
LOCUS ID387082
GENE_SYMBOLSUMO4
GENE NAMEsmall ubiquitin-like modifier 4
SYNONYMNSIDDM5, SMT3H4, SUMO-4, dJ281H8.4
CHROMOSOME6
HOMOLOGENE ID88399
microRNAsNANA
GENE SUMMARY
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Consistent with these in vitro , both albumin protein excretion and phosphorylation of JAK2, STAT1, and STAT3 were attenuated in renal glomeruli by administration of simvastatin in a streptozotocin-induced rat model of HG diabetes. This study demonstrates that simvastatin blocks ANG II-induced activation of the JAK/STAT pathway in the diabetic environment, in vitro and in vivo, and, thereby, provides new insights into the molecular mechanisms underlying early diabetic nephropathy. 2. Multivariate logistic regression analysis showed the SUMO4 M55V variant to be independently associated with the severity of diabetic nephropathy. S-This study indicates that the SUMO4 gene M55V variant is associated with severity of diabetic nephropathy in patients with type 2 diabetes.16449352 , 17229939
Cardiovascular1. SUMO4 Met55Val polymorphism is associated with coronary heart disease in Japanese type 2 diabetes individuals.19410319