TFAM
LOCUS ID7019
GENE_SYMBOLTFAM
GENE NAMEtranscription factor A, mitochondrial
SYNONYMNSTCF6, MTTF1, MTTFA, TCF6L1, TCF6L2, TCF6L3
CHROMOSOME10
HOMOLOGENE ID31139
microRNAsNANA
GENE SUMMARY
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial D replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. In comparison, there was upregulation of mtD and TFAM in 6-wk diabetic mice, suggesting that TFAM activation could be a therapeutic strategy to treat peripheral neuropathy.25944881