| THBS1 |
| LOCUS ID | 7057 | |||||||||||||
| GENE_SYMBOL | THBS1 | |||||||||||||
| GENE NAME | thrombospondin 1 | |||||||||||||
| SYNONYMNS | TSP, THBS, TSP1, TSP-1, THBS-1 | |||||||||||||
| CHROMOSOME | 15 | |||||||||||||
| HOMOLOGENE ID | 31142 |
| microRNAs | miR-320c | 26930277 |
| GENE SUMMARY |
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| The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. In glomeruli of normal kidneys, mRNA and protein levels for THBS1, latent-TGFB1 and CTGF were low. They were increased in the incipient stage of diabetic nephropathy, predominantly in mesangial areas, with further increases at later stages of the disease. Increased glomerular expression of all three factors occurs from the earliest stage of diabetic nephropathy. In contrast to THBS1, CTGF is required for mesangial synthesis of fibronectin stimulated by high glucose or glycated albumin, and is thus a potential therapeutic target. | 16270194 |
| Retinopathy | 1. In diabetes, changes in the TSP-1 level may play a role in shifting the angiogenic balance and contributing to the pathogenesis of diabetic retinopathy | 19365032 |