TIMP2
LOCUS ID7077
GENE_SYMBOLTIMP2
GENE NAMETIMP metallopeptidase inhibitor 2
SYNONYMNSDDC8, CSC-21K
CHROMOSOME17
HOMOLOGENE ID2444
microRNAsNANA
GENE SUMMARY
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are tural inhibitors of the matrix metalloproteises, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteises, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintence of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Losartan can prevent the development of diabetic nephropathy and inhibit MT3-MMP and the TIMP2 mRNA expressions in diabetic rat kidneys.15604066