TIMP3
LOCUS ID7078
GENE_SYMBOLTIMP3
GENE NAMETIMP metallopeptidase inhibitor 3
SYNONYMNSSFD, K222, K222TA2, HSMRK222
CHROMOSOME22
HOMOLOGENE ID36322
microRNAsNANA
GENE SUMMARY
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteises a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal domint disorder Sorsby's fundus dystrophy. [provided by RefSeq Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Our data provide definitive evidence for a critical and selective role of TIMP3 in diabetic renal injury consistent with gene expression findings from human diabetic kidneys.22896043
Retinopathy1. Among the genes encoding for MMPs and TIMPs expressed in retinal pericytes, TIMP3 is uniquely regulated by HOG-LDL. Reduced TIMP3 expression might contribute to microvascular abnormalities in diabetic retinopathy.17676308
Atherosclerosis1. Systemic insulin resistance and subclinical atherosclerosis are associated with decreased IRS2 and TIMP3 expression in circulating monocytes.21984580