| TIMP3 |
| LOCUS ID | 7078 | ||||||||||||||||
| GENE_SYMBOL | TIMP3 | ||||||||||||||||
| GENE NAME | TIMP metallopeptidase inhibitor 3 | ||||||||||||||||
| SYNONYMNS | SFD, K222, K222TA2, HSMRK222 | ||||||||||||||||
| CHROMOSOME | 22 | ||||||||||||||||
| HOMOLOGENE ID | 36322 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteises a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal domint disorder Sorsby's fundus dystrophy. [provided by RefSeq Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Our data provide definitive evidence for a critical and selective role of TIMP3 in diabetic renal injury consistent with gene expression findings from human diabetic kidneys. | 22896043 |
| Retinopathy | 1. Among the genes encoding for MMPs and TIMPs expressed in retinal pericytes, TIMP3 is uniquely regulated by HOG-LDL. Reduced TIMP3 expression might contribute to microvascular abnormalities in diabetic retinopathy. | 17676308 |
| Atherosclerosis | 1. Systemic insulin resistance and subclinical atherosclerosis are associated with decreased IRS2 and TIMP3 expression in circulating monocytes. | 21984580 |