TIMP4
LOCUS ID7079
GENE_SYMBOLTIMP4
GENE NAMETIMP metallopeptidase inhibitor 4
SYNONYMNSTIMP-4
CHROMOSOME3
HOMOLOGENE ID37748
microRNAsNANA
GENE SUMMARY
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Tuberculosis1. Heightened plasma levels of heme oxygenase-1 and tissue inhibitor of metalloproteinase-4 as well as elevated peripheral neutrophil counts are associated with TB-diabetes comorbidity.24458266