TSC22D1
LOCUS ID8848
GENE_SYMBOLTSC22D1
GENE NAMETSC22 domain family member 1
SYNONYMNSPtg-2, TSC22, TGFB1I4
CHROMOSOME13
HOMOLOGENE ID7573
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type triuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Altertively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These findings suggest that the TSC-22 gene (-396) A allele is associated with an increasing risk of the diabetic nephropathy.12757981