| TWIST2 |
| LOCUS ID | 117581 | ||||||||||
| GENE_SYMBOL | TWIST2 | ||||||||||
| GENE NAME | twist family bHLH tr | ||||||||||
| SYNONYMNS | AMS FFDD3 BBRSAY DERMO1 SETLSS bHLHa39 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 40594 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.In vitro, TWIST2 overexpression ameliorated hepatocellular steatosis, inhibited inflammation, and improved mitochondrial content and function with a fibroblast growth factor 21 (FGF21)-dependent pattern.? | 31648561 |