| UCN3 |
| LOCUS ID | 114131 | ||||||||||
| GENE_SYMBOL | UCN3 | ||||||||||
| GENE NAME | urocortin 3 | ||||||||||
| SYNONYMNS | SCP SPC UCNIII | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 49959 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cell |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. UCN3 levels positively correlated with hs-CRP in PCOS group (r=0.391, p=0.004). The results of this study support the presence of increased UCN3 levels for the association of inflammation with PCOS. | 26488073 |