UHRF1
LOCUS ID29128
GENE_SYMBOLUHRF1
GENE NAMEubiquitin-like with PHD and ring finger domains 1
SYNONYMNSNp95, hNP95, ICBP90, RNF106, hUHRF1, huNp95
CHROMOSOME19
HOMOLOGENE ID7866
microRNAsNANA
GENE SUMMARY
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific D sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent D damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The expressions of UHRF1 and DNMT1 were increased in DN patients.26049093