| miRNA |
Gene |
Observation |
PMID |
| miRNA | Gene | Observation | PMID |
| hsa-let-7b | NA | 1:let-7b, miR-142, miR-144, and miR-29a in plasma may be important markers of neuroendocrine stress response and may play a role in the pathogenesis of T2DM and IR. 2: Forty-eight miRNAs showed significant correlations with clinical parameters; stepwise regression retained let-7b, miR-144-5p, miR-34 | 29643835, 28834285 |
| hsa-let-7i-3p | MAC | Indeed, a urinary EV miRNA signature was found to comprise increased levels of let-7i-3p, miR-24-3p and miR-27b-3p, and decreased levels of miR-15b-5p, to identify patients with MIC. | 30165157 |
| hsa-mir-125a | NA | Up regulation of miR-125a in WAT of type 2 Diabetes mellitus have been observed. | 30150203 |
| hsa-miR-125b | NA | alteration of miR-34a and miR-125b exists in patients with T2DM, which may be involved in the pathogenesis of T2DM, and could be a potential novel biomarker of T2DM. | 29285097 |
| hsa-miR-126-3p | NA | Three miRNAs (miR-126-3p, miR-28-3p miR-486-5p) were dysregulated in prediabetes compared to screen-detected diabetes. | 30093963 |
| hsa-mir-132 | NA | 1: On the contrary, the less abundant miRNAs such as miR-212/miR-132, miR-335, miR-130a/b and miR-152 are deregulated in T2D islets, wherein the latter three miRNAs were shown to play key roles in regulating ?-cell metabolism. | 30230181 |
| hsa-miR-140 | NA | miRNAs associated with platelet function and reactivity (miR-223, miR-126, miR-197, miR-191, miR-21, miR-150, miR-155, miR-140, miR-96, miR-98) that should be evaluated as novel biomarkers to improve diagnostics and treatment of CVD. | 29615970 |
| hsa-miR-142 | NA | let-7b, miR-142, miR-144, and miR-29a in plasma may be important markers of neuroendocrine stress response and may play a role in the pathogenesis of T2DM and IR. | 29643835 |
| hsa-miR-144-5p | NA | Forty-eight miRNAs showed significant correlations with clinical parameters; stepwise regression retained let-7b, miR-144-5p, miR-34a, and miR-532-5p in a model predictive of insulin resistance (R2 = 0.57, P = 7.5 ? 10-8 ). | 28834285 |
| hsa-miR-146a | NA | miR-146a circulating levels were significantly elevated in controls compared with T2D patients. In addition, we identified that rs2910164-C allele is associated with reduced expression levels of the miR-146a but not its mRNAs targets and cytokine levels in diabetic patients. | 29058209 |
| hsa-miR-146b | NA | Of these 3 miRNAs, miR-486 was implicated in accelerating preadipocyte proliferation and myotube glucose intolerance, miR-146b and miR-15b were engaged in the suppression of high concentration glucose-induced pancreatic insulin secretion, and they all contributed to the pathological processes of obe | 28966078 |
| hsa-miR-148b | NA | 16 stress-related miRNAs were significantly dysregulated in T2DM. MiR-148b, miR-223, miR-130a, miR-19a, miR-26b and miR-27b were selected as potential circulating biomarkers of T2DM. In addition, miR-146a and miR-21 were identified as potential tissue biomarkers of T2DM. | 29341487 |
| hsa-mir-150 | NA | Deregulated plasma levels of miR-150, miR-30a-5p, miR-15a, and miR-375 were observed years before the onset of T2DM and pre-DM and could be used to evaluate the risk of developing the disease, which may improve prediction and prevention among individuals at high risk for T2DM. | 30598522 |
| hsa-mir-15a | NA | Deregulated plasma levels of miR-150, miR-30a-5p, miR-15a, and miR-375 were observed years before the onset of T2DM and pre-DM and could be used to evaluate the risk of developing the disease, which may improve prediction and prevention among individuals at high risk for T2DM. | 30598522 |
| hsa-miR-15a-5p | NA | MiR-362-3p, miR-877-3p, miR-150-5p, and miR-15a-5p might be novel biomarkers for incipient DKD. | 29038788 |
| hsa-miR-15b-5p | MAC | Indeed, a urinary EV miRNA signature was found to comprise increased levels of let-7i-3p, miR-24-3p and miR-27b-3p, and decreased levels of miR-15b-5p, to identify patients with MIC. | 30165157 |
| hsa-miR-18a | NA | MiR-18a and miR-34c in PBMCs may be important marker of stress reaction and may play a role in vulnerability to T2DM as well as IR. | 28661068 |
| hsa-miR-191 | NA | 1:miRNAs associated with platelet function and reactivity (miR-223, miR-126, miR-197, miR-191, miR-21, miR-150, miR-155, miR-140, miR-96, miR-98) that should be evaluated as novel biomarkers to improve diagnostics and treatment of CVD. 2: These results reveal a mechanism by which miR-191 is involve | 29615970, 28963693 |
| hsa-miR-193b-3p | NA | Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls. | 30083267 |
| hsa-mir-196a-2 | NA | The aim of the study was to evaluate the association of miRNA-146a G/C (rs2910164), and miRNA-196a2 C/T (rs11614913) polymorphisms with the presence of coronary artery disease (CAD) and/or restenosis in patients with coronary stent. | 30560371 |
| hsa-miR-197 | NA | miRNAs associated with platelet function and reactivity (miR-223, miR-126, miR-197, miR-191, miR-21, miR-150, miR-155, miR-140, miR-96, miR-98) that should be evaluated as novel biomarkers to improve diagnostics and treatment of CVD. | 29615970 |
| hsa-miR-19a | NA | 16 stress-related miRNAs were significantly dysregulated in T2DM. MiR-148b, miR-223, miR-130a, miR-19a, miR-26b and miR-27b were selected as potential circulating biomarkers of T2DM. In addition, miR-146a and miR-21 were identified as potential tissue biomarkers of T2DM. | 29341487 |
| hsa-miR-202 | CACNA1E | Identification of the subpaths of each subtype indicated that the subpath related to subtype 1 was miRNA (miR)?202/calcium voltage?gated channel subunit ?1 (CACNA1E)/type II diabetes mellitus." | 29981420 |
| hsa-miR-20b | NA | Plasma miR-17, miR-20a, miR-20b, and miR-122 were up-regulated in T2DM patients with NAFLD complicated compared in those without NAFLD (P < 0.05). | 30030064 |
| hsa-mir-212 | NA | 1:On the contrary, the less abundant miRNAs such as miR-212/miR-132, miR-335, miR-130a/b and miR-152 are deregulated in T2D islets, wherein the latter three miRNAs were shown to play key roles in regulating ?-cell metabolism. 2:dysregulated miRNA expression exacerbates ?-cell dysfunction, | 30230181 |
| hsa-miR-223 | NA | 1:miRN In this manuscript, we provide an outline of miRNAs associated with platelet function and reactivity (miR-223, miR-126, miR-197, miR-191, miR-21, miR-150, miR-155, miR-140, miR-96, miR-98) that should be evaluated as novel biomarkers to improve diagnostics and treatment of CVD. 2MiR-148b, mi | 29615970, 29341487 |
| hsa-miR-24-3p | MAC | Indeed, a urinary EV miRNA signature was found to comprise increased levels of let-7i-3p, miR-24-3p and miR-27b-3p, and decreased levels of miR-15b-5p, to identify patients with MIC. | 30165157 |
| hsa-miR-26b | NA | 16 stress-related miRNAs were significantly dysregulated in T2DM. MiR-148b, miR-223, miR-130a, miR-19a, miR-26b and miR-27b were selected as potential circulating biomarkers of T2DM. In addition, miR-146a and miR-21 were identified as potential tissue biomarkers of T2DM. | 29341487 |
| hsa-miR-26b-5p | NA | Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls. | 30083267 |
| hsa-miR-27b | NA | 16 stress-related miRNAs were significantly dysregulated in T2DM. MiR-148b, miR-223, miR-130a, miR-19a, miR-26b and miR-27b were selected as potential circulating biomarkers of T2DM. In addition, miR-146a and miR-21 were identified as potential tissue biomarkers of T2DM. | 29341487 |
| hsa-miR-27b-3p | MAC | Indeed, a urinary EV miRNA signature was found to comprise increased levels of let-7i-3p, miR-24-3p and miR-27b-3p, and decreased levels of miR-15b-5p, to identify patients with MIC. | 30165157 |
| hsa-mir-28-3p | HbA1c | 1.Patients with low miR-103, miR-28-3p, miR-29a, and miR-9 and high miR-30a-5p and miR-150 circulating levels have a higher risk of disease (HR = 11.27; 95% CI = 2.61-48.65). 2.For instance, three miRNAs (miR-126-3p, miR-28-3p miR-486-5p) were dysregulated in prediabetes compared to screen-detected | 30195754, 30093963 |
| hsa-miR-296-5p | bak/bax, bcl-2 | VSMCs, from human atherosclerotic arteries of individuals with T2D, express low bak/bax and high bcl-2 and miR-296-5p levels. | 29386225 |
| hsa-miR-30a-5p | NA | Deregulated plasma levels of miR-150, miR-30a-5p, miR-15a, and miR-375 were observed years before the onset of T2DM and pre-DM and could be used to evaluate the risk of developing the disease, which may improve prediction and prevention among individuals at high risk for T2DM. | 30598522 |
| hsa-miR-30b-5p | TGFBRAP1,TGFBR2 | The expression of has-miR-30b-5p and has-miR-93-5p was linearly increased across TT, TC, and CC genotypes of rs2241797 in NGT, Ptrend values were 0.024 and 0.016, respectively. | 30461200 |
| hsa-mir-31 | IL-6,ICAM-1,Satb2 | 1:Serum miR-31 may be a biomarker for DN in T2D patients. The regulation of this miRNA seems to be related to the recruitment of leukocytes to vascular walls induced by pro-inflammatory and adhesion molecules.2. In conclusion, our results indicate that up-regulation of miR-31 may underlie endothelia | 30355913, 29566110 |
| hsa-miR-323 | NA | In cross sectional analysis at year 3, the top differentially expressed biomarkers in people with IGT/ reduced ?-cell glucose sensitivity were adiponectin, alpha1-antitrypsin (known to regulate adiponectin levels), endocan, miR-181a, miR-342, and miR-323. | 28846711 |
| hsa-miR-342 | NA | In cross sectional analysis at year 3, the top differentially expressed biomarkers in people with IGT/ reduced ?-cell glucose sensitivity were adiponectin, alpha1-antitrypsin (known to regulate adiponectin levels), endocan, miR-181a, miR-342, and miR-323. | 28846711 |
| hsa-miR-34c | NA | MiR-18a and miR-34c in PBMCs may be important marker of stress reaction and may play a role in vulnerability to T2DM as well as IR. | 28661068 |
| hsa-miR-362-3p | NA | MiR-362-3p, miR-877-3p, miR-150-5p, and miR-15a-5p might be novel biomarkers for incipient DKD. | 29038788 |
| hsa-miR-374a-5p | NA | Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls. | 30083267 |
| hsa-miR-377 | NA | The results suggested that blood?based miR?377 and miR?192 may serve as potential biomarkers for early detection of DN. | 29845236 |
| hsa-miR-409-3p | NA | Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls. | 30083267 |
| hsa-miR-410 | LPL | evaluated rs13702 (C/T) polymorphism located in miRNA-410 binding site of LPL gene in subset of Iranian T2DM patients and their normal counterparts. | 29930919 |
| hsa-mir-423-3p | BMI and HbA1c | Compared with baseline, the post-training levels of miR-423-3p, miR-451a, and miR-766-3p were significantly up-regulated, irrespective of exercise type (P < 0.0026; 0.05/19), and targeted upstream pathways relevant to fatty acids biosynthesis and metabolic regulation. | 30445461 |
| hsa-mir-4463 | PNUTS | miR-4463 was elevated in the vascular tissues of patients with T2DM and ASO. Down regulation of miR-4463 attenuates cell apoptosis by directly enhancing PNUTS expression to promote PTEN nuclear localization, subsequently activating AKT signaling pathway in HUVECs under HG and/ or hypoxic conditions. | 30244253 |
| hsa-miR-448 | NA | miR-448 and its target gene SIRT1 can serve as prognostic indicators for obese T2DM patients after laparoscopic bariatric surgery. | 29428938 |
| hsa-mir-451a | BMI and HbA1c | Compared with baseline, the post-training levels of miR-423-3p, miR-451a, and miR-766-3p were significantly up-regulated, irrespective of exercise type (P < 0.0026; 0.05/19), and targeted upstream pathways relevant to fatty acids biosynthesis and metabolic regulation. | 30445461 |
| hsa-miR-486 | NA | Of these 3 miRNAs, miR-486 was implicated in accelerating preadipocyte proliferation and myotube glucose intolerance, miR-146b and miR-15b were engaged in the suppression of high concentration glucose-induced pancreatic insulin secretion, and they all contributed to the pathological processes of obe | 28966078 |
| hsa-miR-486-5p | NA | Three miRNAs (miR-126-3p, miR-28-3p miR-486-5p) were dysregulated in prediabetes compared to screen-detected diabetes. | 30093963 |
| hsa-miR-498 | CircANKRD36 | Taken together, circANKRD36 may be involved in T2DM and inflammation?associated pathways via interaction with miRNAs, including hsa?miR?3614?3p, hsa?miR?498, and hsa?miR?501?5p. | 30066828 |
| hsa-miR-501-5p | CircANKRD36 | Taken together, circANKRD36 may be involved in T2DM and inflammation?associated pathways via interaction with miRNAs, including hsa?miR?3614?3p, hsa?miR?498, and hsa?miR?501?5p. | 30066828 |
| hsa-miR-532-5p | NA | Forty-eight miRNAs showed significant correlations with clinical parameters; stepwise regression retained let-7b, miR-144-5p, miR-34a, and miR-532-5p in a model predictive of insulin resistance (R2 = 0.57, P = 7.5 ? 10-8 ). | 28834285 |
| hsa-miR-7 | NA | Reduction of circulating miR-7 and miR-192, accompanied by elevation of miR-152, reflects a beneficial metabolic response to vitamin D treatment in people with prediabetes. These miRNAs may be useful biomarkers in diabetes prevention trials and other studies of vitamin D. | 28945992 |
| hsa-mir-766-3p | BMI and HbA1c | Compared with baseline, the post-training levels of miR-423-3p, miR-451a, and miR-766-3p were significantly up-regulated, irrespective of exercise type (P < 0.0026; 0.05/19), and targeted upstream pathways relevant to fatty acids biosynthesis and metabolic regulation. | 30445461 |
| hsa-miR-877-3p | NA | MiR-362-3p, miR-877-3p, miR-150-5p, and miR-15a-5p might be novel biomarkers for incipient DKD. | 29038788 |
| hsa-miR-93-5p | TGFBRAP1,TGFBR3 | The expression of has-miR-30b-5p and has-miR-93-5p was linearly increased across TT, TC, and CC genotypes of rs2241797 in NGT, Ptrend values were 0.024 and 0.016, respectively.Our findings suggest that genetic polymorphisms of TGFBRAP1 may contribute to the genetic susceptibility of T2DM by mediatin | 30461200 |
| hsa-miR-95-3p | NA | Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls. | 30083267 |
| hsa-miR-98 | NA | miRNAs associated with platelet function and reactivity (miR-223, miR-126, miR-197, miR-191, miR-21, miR-150, miR-155, miR-140, miR-96, miR-98) that should be evaluated as novel biomarkers to improve diagnostics and treatment of CVD. | 29615970 |
| let-7d | NA | While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with increased level of miR-122, miR-99 and decreased level of let-7d, miR-18a, miR-18b, miR-23a, | 29200427 |
| miR-1 | ET-1 | 25mM glucose decreased miR-1 expression and increased ET-1 mRNA and protein levels.These results indicate a novel glucose-induced mechanism of tissue damage, in which miR-1 regulates ET-1 expressions in diabetes. Identifying such mechanisms may lead to RNA based treatment for diabetic complications. | 24394957 |
| miR-100 | NA | Additionally, our in-vitro findings, and the miR-100 expression patterns in site-specific adipose tissue suggest miR-100 to modulate IGFR, mTOR and mediate adipogenesis. | 26973292 |
| miR-103/107 | CAV1 | We demonstrate that caveolin-1 is upregulated upon miR-103/107 inactivation in adipocytes and that this is concomitant with stabilization of the insulin receptor, enhanced insulin signalling, decreased adipocyte size and enhanced insulin-stimulated glucose uptake. | 21654750 |
| miR-103b | SFRP4 | CONCLUSIONS: The results suggest that platelet-derived miR-103b could negatively regulate the expression of SFRP4 mRNA/protein in pre-DM2, indicating that miR-103b could be a novel biomarker for the early diagnosis of DM2. | 25820527 |
| miR-106a | HIF1A,VEGF | Over-expression of a common miRNA (miR-106a) significantly reduced the expression of HIF1A and VEGF and prevented high glucose-induced increased permeability. | 24018047 |
| miR-106b | UCP1 | In addition, ectopic expression of miR-106b and miR-93 suppressed the mRNA level of Ucp1, a selective hallmark of brown adipocytes. Furthermore, the expression levels of miR-106b and miR-93 are higher in brown adipose tissues of high fat diet-induced obese mice compared to control mice. | 23954633 |
| miR-106b | SLC2A4 | Overexpression of miR-106b, miR-27a and miR-30d in L6 cells decreased glucose consumption and glucose uptake, and reduced the expression of GLUT4, MAPK 14 and PI3K regulatory subunit beta. | 27165190 |
| miR-10a | CREB1,HDAC3 | Contrarily, HDAC3 overexpression mediated by lentivirus decreased miR-10a content, and enhanced ACR value, CREB1 and FN formation in naive mice.Knockdown of HDAC3 with siRNA significantly caused the increase of miR-10a, resulting in the decrease in CREB1 and FN expression in kidney of HFD/STZ mice. | 27292126 |
| miR-10a | NA | Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are a | 22156553 |
| miR-10b | NA | Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are a | 22156553 |
| miR-122 | SLC7A1 | miR-122 binding to 3UTR depresses SLC7A1 level | 19067360 |
| miR-122 | NA | Taken together, our results provide new evidence that miR-122-regulated HCBP6 functions as a sensor protein to maintain intrahepatocyte TG levels. | 25855506 |
| miR-124 | FOXA2 | Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are a | 22156553 |
| MiR-124a | NA | MiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM. | 26897751 |
| miR-125b-1 | NFKB | The expression of miR-125b-1 regulated by NF-KB has been reported in diverse cell types under various stimuli, this study found that its expression was also significantly regulated by NF-KB in TNFA-stimulated HeLa and HepG2 cells. | 24418602 |
| miR126 | NA | Notably, miR-126 is the only miRNA that showed significantly reduced expression in susceptible individuals and T2DM patients compared to normal individuals, suggesting that miR-126 in circulation may serve as a potential biomarker for early identification of susceptible individuals to T2DM. | 24455723 |
| miR-126 | NA | Circulating miR-126 may serve as a biomarker for predicting patients with T2D and diabetic CAD. | 27321479 |
| miR1276 | CASP9,BMP2 | The expression of miR-125b-1 regulated by NF-?B has been reported in diverse cell types under various stimuli, this study found that its expression was also significantly regulated by NF-?B in TNF?-stimulated HeLa and HepG2 cells. | 24418602 |
| miR-128-3p | ISL1 | miR-128-3p aggravates cardiovascular calcification and IR in T2DM rats by downregulating ISL1 through the activation of the Wnt pathway. Thus, miR-128-3p may serve as a potential target for the treatment of T2DM. | 30341898 |
| miR-130a | RUNX3 | We recently reported that downregulated miR-130a in patients with Type 2 diabetes mellitus (DM) results in EPC dysfunction, including increased apoptosis, likely via its target runt-related transcription factor 3 (Runx3). | 24750349 |
| miR-130b | NA | Our findings suggest that serum miR-130b may be a new biomarker for the early diagnosis of DN in T2DM. Circulating miR-130b may possibly be involved in the pathological mechanism of DN, such as lipid metabolic disorders, oxidative stress, extracellular matrix deposition and renal fibrosis. | 25952368 |
| miR-143 | ORP8 | Conversely, mice deficient for the miR-143-145 cluster are protected from the development of obesity-associated insulin resistance. | 21441927 |
| miR-143 | ORP8 | This inhibition of insulin signaling by conditioned media (CM) and miR-143 is associated with a reduction in the expression of the oxysterol-binding protein-related protein 8 (ORP8). | 24333576 |
| miR-144 | NA | Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. | 22156553 |
| miR-144 | IRS1 | Increased expression of miR-144 has been found to directly downregulate insulin receptor substrate 1 (IRS1), which is involved in insulin signaling at both the mRNA and protein level.Higher expression of miR-144 was significantly associated with T2D in Swedes (OR=2.43, p=0.035). | 24497980 |
| miR146 | IRAK1,TRAF6 | Prolonged exposure of the beta-cell line MIN6B1 and pancreatic islets to palmitate causes a time- and dose-dependent increase of miR34a and miR146. Elevated levels of these miRNAs are also observed in islets of diabetic db/db mice.? | 18633110 |
| miR-146a | IRAK1,TRAF6,NFKB | MiR-146a expression was significantly downregulated in diabetic mouse wounds. | 22851573 |
| miR-148 | NA | While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with increased level of miR-122, miR-99 and decreased level of let-7d, miR-18a, miR-18b, miR-23a, | 29200427 |
| miR-149 | PARP2 | In addition, skeletal muscles from HFD-fed obese mice exhibit low levels of miR-149 and high levels of PARP-2, and they show reduced mitochondrial function and biogenesis due to a decreased activation of the SIRT-1/PGC-1? pathway, suggesting that mitochondrial dysfunction in the skeletal muscle of | 24757201 |
| miR-152 | PTEN | Finally, phosphatase and tensin homolog (PTEN) was identified as a direct target of miR-152 to mediate hepatic glycogen synthesis. | 26996529 |
| miR-155 | NR1H3 | miR-155 was upregulated in livers of obese mice, and that this increased expression was primarily detected in CD11b+ macrophage cells. | 23991091 |
| miR-15b | INSR | Furthermore, the overexpression of miR-15b suppressed the protein expression of INSR through targeting INSR 3' untranslated region directly, resulting in an impairment of the insulin signaling and glycogen synthesis in hepatocytes. | 26179126 |
| miR-15b | CCND1 | The up-regulated miR-15b inhibited pancreatic beta-cell proliferation via targeting cyclin D1 and cyclin D2. Inhibition of miR-15b in LP islet cells restored beta-cell proliferation and insulin secretion. | 27754789 |
| miR-16 | MEF2A,SLC2A4 | Further, ectopic expression of miR-16 enhanced insulin stimulated glucose uptake in skeletal myoblasts via the up-regulation of GLUT4 and MEF2A, two key players involved in insulin stimulated glucose uptake. | 26453808 |
| miR-17 | TXNIP | In contrast, IFN? increased pro-apoptotic TXNIP post-transcriptionally via induction of endoplasmic reticulum stress, activation of inositol-requiring enzyme 1? (IRE1?), and suppression of miR-17, a microRNA that targets and down-regulates TXNIP. | 26858253 |
| mir-181a | SIRT1 | Inhibition of miR-181a by antisense oligonucleotides increases SIRT1 protein levels and activity, and improves insulin sensitivity in hepatocytes. | 22476949 |
| miR-181b | NA | NEAT1 was potentially communicated with mTOR signalling target protein mLST8 via the association with miR-181b. | 28643459 |
| miR-182 | NA | Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are a | 22156553 |
| miR-183 | NA | Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are a | 22156553 |
| miR-184 | SLC25A22 | miR-184 inhibits insulin secretion in the MIN6 pancreatic beta-cell line through the repression of its target Slc25a22, a mitochondrial glutamate carrier. | 24109547 |
| miR-187 | HIPK3 | The gene encoding homeodomain-interacting protein kinase-3 (HIPK3), a known regulator of insulin secretion, was identified as a direct target of miR-187 and displayed reduced expression in islets from individuals with type 2 diabetes. | 24149837 |
| miR-18a | NA | While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with increased level of miR-122, miR-99 and decreased level of let-7d, miR-18a, miR-18b, miR-23a, | 29200427 |
| miR-18b | NA | While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with increased level of miR-122, miR-99 and decreased level of let-7d, miR-18a, miR-18b, miR-23a, | 29200427 |
| miR-192 | ALB | CONCLUSIONS: These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN. | 26881255 |
| miR-192 | ALDH3A2 | SCD and ALDH3A2 were demonstrated to be direct targets of miR-192*. To conclude, the present data identify miR-192* as a novel controller of adipocyte differentiation and lipid homeostasis. | 26747651 |
| miR-193-5p | IGF2 | MiR-193-5p is an active angiogenic factor in diabetic cardiomyopathy, possibly through inverse regulation on its downstream IGF2 gene. | 28735866 |
| miR-194 | AKT1 | When miR-194 was down-regulated in vitro, western blot analysis showed an increased phosphorylation of AKT and GSK3beta in response to insulin, and an increase in expression of proteins controlling mitochondrial oxidative phosphorylation. | 27163678 |
| miR-195 | SIRT1 | These studies identified a novel mechanism whereby miR-195 regulates SIRT1-mediated tissue damage in diabetic retinopathy. | 24570140 |
| miR-199a-3p | NA | Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are a | 22156553 |
| miR-199a-3p | LEP | FFA, TNF-alpha, IL-6 and leptin significantly induced miR-199a-3p expression in mature human adipocytes, while resistin had the opposite effect. miR-199a-3p may represent a factor in the modulation of obesity-associated IR and inflammatory responses. | 27279151 |
| miR-199b-5p | KL | The increased serum klotho, mediated by miR-199b-5p, is a possible mechanism by which atrasentan prevents renal tubular injury in DN. | 26813039 |
| miR-200a | NA | Adipose tissue-specific down-regulation of miR-200a and miR-200b and the up-regulation of miR-342-3p, miR-335-5p, and miR-335-3p were observed. | 24758184 |
| miR-200b | VEGF | Transfection of endothelial cells and intravitreal injection of miR-200b mimic prevented diabetes-induced increased VEGF mRNA and protein. | 21357793 |
| miR-200c | NA | To unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated | 28776684 |
| miR-203 | SOCS3 | H.pylori infection could upregulate SOCS3, a well-known insulin signaling inhibitor, by downregulating miR-203. | 25689935 |
| miR-203a-3p | GRP78 | These findings provided evidence that miR?203a?3p may have a functional role in endoplasmic reticulum stress (ERS) signaling in the liver of T2DM GK rats. | 29257218 |
| miR-204 | NA | Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are a | 22156553 |
| miR-206 | NA | Chow- and HFD-fed miR-206 KO mice have improved glucose tolerance and GSIS but unaltered insulin sensitivity. | 27221121 |
| miR-21 | PTEN | Our data demonstrate that miR-21 reverses high glucose and high insulin induced IR in 3T3-L1 adipocytes, possibly through modulating the PTEN-AKT pathway, and miR-21 may be a new therapeutic target for metabolic diseases such as T2DM and obesity. | 22956257 |
| miR-21 | SMAD7 | The therapeutic potential of miR-21 in diabetic kidney injury was examined in db/db mice by an ultrasound-microbubble-mediated miR-21 small hairpin RNA transfer. | 23292313 |
| miR-211 | NA | Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are a | 22156553 |
| miR-214 | MEG3 | In conclusion, MEG3 promoted hepatic insulin resistance by serving as a ceRNA of miR?214 to facilitate ATF4 expression. These data provide insight into the molecular mechanism of MEG3 involvement in the development of type 2 diabetes mellitus. | 30431065 |
| miR-216b | NA | MicroRNA-216b was overexposed in diabetic MMECs and its downregulation may actively enhance angiogenesis in diabetic angiopathy through inverse regulation on FZD5. | 29477872 |
| miR-219 | NA | the upregulation of miR-219 decreases LTP inhibition and hippocampal neuronal cell apoptosis in T2DM mice by downregulating the NMDAR signaling pathway, therefore suggesting that MiR-219 might be a future therapeutic strategy for T2DM. | 29804319 |
| miR-219-2-3p | NA | Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are a | 22156553 |
| miR-221 | ADIPOR1,ETS1 | Expression levels of miR-221 were positively correlated with BMI (particularly in women) and fasting insulin concentrations, while the levels of miR-193a-3p and miR-193b-5p were negatively correlated with BMI; | 23756832 |
| miR-222 | NA | While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with increased level of miR-122, miR-99 and decreased level of let-7d, miR-18a, miR-18b, miR-23a, | 29200427 |
| miR-22-3p | NA | Furthermore, in vivo silencing of miR-22-3p by antagomiR administration lowered random as well as fasting glucose levels in diabetic mice. miR-22-3p antagonism improved glucose tolerance and insulin sensitivity. | 26193896 |
| miR-23a | NA | While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with increased level of miR-122, miR-99 and decreased level of let-7d, miR-18a, miR-18b, miR-23a, | 29200427 |
| miR-24 | HNF1A, NEUROD1 | Overexpression of miR-24 inhibited insulin secretion and ?-cell proliferation, potentially involving 351 downregulated genes. | 23761103 |
| miR-25 | NOX4 | among 5 miRNAs, which are predicted to have a binding capacity to rat NOX4, the miRNA-25 level was significantly reduced both in the kidney from diabetic rats and in high glucose-treated mesangial cells, accompanied by the increases in NOX4 expression levels. | 21071935 |
| miR-25 | PTBP1 | Despite the increase in PTBP1 protein in the pancreas of diabetic rats, we observed insulin expression to be reduced alongside upregulation of miR-25 and miR-92a, suggesting an intricate regulation of insulin (bio)synthesis at its mRNA level. | 24084692 |
| miR-26a | ID1 | Diabetic dermal wounds treated with LNA-anti-miR-26a had increased expression of ID1, a downstream modulator or SMAD1, and decreased expression of the cell cycle inhibitor p27. | 26776318 |
| miR-27a | SLC2A4 | CONCLUSION: Our data suggested that miR-106b, miR-27a and miR-30d play crucial roles in the regulation of glucose metabolism by targeting the GLUT4 signalling pathway in L6 cells. | 27165190 |
| miR-27a | NA | Overexpression of miR-106b, miR-27a and miR-30d in L6 cells decreased glucose consumption and glucose uptake, and reduced the expression of GLUT4, MAPK 14 and PI3K regulatory subunit beta. | 27165190 |
| miR-27b | NA | miR-27b prevents EPC apoptosis in Type 2 diabetic mice, at least in part, by suppressing p53 and the Bax/Bcl-2 ratio. These findings may provide a mechanistic basis for rescuing BMPC dysfunction in diabetes for successful autologous cell therapy. | 28698281 |
| miR-28 | NA | While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with increased level of miR-122, miR-99 and decreased level of let-7d, miR-18a, miR-18b, miR-23a, | 29200427 |
| miR29 | FOXA2 | We present evidence that miR-29 expression in human hepatoma cells is controlled in part by FOXA2, which is known to play a critical role in hepatic energy homeostasis. | 24722248 |
| miR-29 | NA | the miR-29 family negatively regulates glucose metabolism by inhibiting SPARC expression. | 29462611 |
| miR29a | NA | Adenovirus-mediated overexpression of miR-29a/b/c in 3T3-L1 adipocytes could largely repress insulin-stimulated glucose uptake, presumably through inhibiting Akt activation. | 17652184 |
| miR-29a-3p | Mir29b-1/a | Intraluminal delivery of miR-29a-3p or miR-29b-3p mimics restored normal endothelium-dependent vasodilation (EDVD) in T2DM arterioles that otherwise exhibited impaired EDVD Intraluminal delivery of anti-miR-29b-3p in arterioles from non-DM human subjects or rats or targeted mutation of Mir29b-1/a g | 29374012 |
| miR-29b | INSIG1, CAV2 | Adenovirus-mediated overexpression of miR-29a/b/c in 3T3-L1 adipocytes could largely repress insulin-stimulated glucose uptake, presumably through inhibiting Akt activation. | 17652184 |
| miR-29b-3p | Mir29b-1/a | Intraluminal delivery of miR-29a-3p or miR-29b-3p mimics restored normal endothelium-dependent vasodilation (EDVD) in T2DM arterioles that otherwise exhibited impaired EDVD Intraluminal delivery of anti-miR-29b-3p in arterioles from non-DM human subjects or rats or targeted mutation of Mir29b-1/a g | 29374012 |
| miR-29c | NA | Adenovirus-mediated overexpression of miR-29a/b/c in 3T3-L1 adipocytes could largely repress insulin-stimulated glucose uptake, presumably through inhibiting Akt activation. | 17652184 |
| miR-29c | SPRY1 | These findings identify miR-29c as a novel target in diabetic nephropathy and provide new insights into the role of miR-29c in a previously unrecognized signaling cascade involving Spry1 and Rho kinase activation. | 21310958 |
| miR-301a | NA | To unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated | 28776684 |
| miR-301b | NA | The results indicate that translational regulation by miR-301b mediates upregulated expression of cardiac AMPD3 protein in OLETF, which potentially reduces the adenine nucleotide pool at the time of increased work load. | 29733818 |
| miR-30d | SLC2A4 | CONCLUSION: Our data suggested that miR-106b, miR-27a and miR-30d play crucial roles in the regulation of glucose metabolism by targeting the GLUT4 signalling pathway in L6 cells. | 27165190 |
| miR-30d | NA | MiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM. | 26897751 |
| miR-30d | NA | While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with increased level of miR-122, miR-99 and decreased level of let-7d, miR-18a, miR-18b, miR-23a, | 29200427 |
| miR320 | PI3-K | Anti-miR-320 oligo was found to regulate insulin resistance in adipocytes by improving insulin?PI3-K signalling pathways. | 19473196 |
| miR-320c | THBS1 | Deregulated miR-320c, which might have an impact on the TGF-beta-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies. | 26930277 |
| miR-322 | NA | To unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated | 28776684 |
| miR-327 | FGF10 | We identify miR-327 as one of the most downregulated miRNAs targeting growth factors in the stromal-vascular fraction (SVF) under conditions that promote white adipose tissue (WAT) browning in mice. | 29233981 |
| miR-328 | BAAT | Analyses of differential microRNA expression during preadipocyte commitment and mouse models of progeria, longevity and DIO identified miR-328 as a regulator of BAT differentiation. | 26900752 |
| miR-330-5p | NA | miR-330-5p served as a regulator of the M2 polarization and miR-330-5p/Tim-3 axis potentially down-regulated insulin resistance in diabetes, probably through enhancing the M2 polarization of macrophage. | 29433065 |
| miR-331 | NA | To unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated | 28776684 |
| mir-335 | NA | On the contrary, the less abundant miRNAs such as miR-212/miR-132, miR-335, miR-130a/b and miR-152 are deregulated in T2D islets, wherein the latter three miRNAs were shown to play key roles in regulating ?-cell metabolism. | 30230181 |
| miR335-3p | NA | Adipose tissue-specific down-regulation of miR-200a and miR-200b and the up-regulation of miR-342-3p, miR-335-5p, and miR-335-3p were observed. | 24758184 |
| miR335-5p | NA | Adipose tissue-specific down-regulation of miR-200a and miR-200b and the up-regulation of miR-342-3p, miR-335-5p, and miR-335-3p were observed. | 24758184 |
| miR-33-5p | NA | Decreased miR-33-5p levels were found in the urine of db/db mice and type 2 DM patients, and miR-33-55p levels negatively correlated with albuminuria. Angpt2 leads to MC apoptosis via the miR-33-5p-SOCS5 loop in DN. miR-33-5p is predictive of kidney injury in DN. | 30414568 |
| miR-338 | NA | Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are a | 22156553 |
| miR-33a | ABCA1 | Adenoviral miR-33a overexpression in human or mouse islets reduced ABCA1 expression, decreased glucose-stimulated insulin secretion, and increased cholesterol levels. | 22315319 |
| miR-33b | 2-DOG | miR-33b overexpression reduces insulin-induced 2-deoyxglucose (2-DOG) uptake in hepatic cells, suggesting that miR-33 plays a key role in regulating insulin signaling | 21946517 |
| miR342-3p | NA | Adipose tissue-specific down-regulation of miR-200a and miR-200b and the up-regulation of miR-342-3p, miR-335-5p, and miR-335-3p were observed. | 24758184 |
| miR-346 | NA | TNF-alpha suppression of VDR in PBMCs and HK2 cells is mediated by miR-346. | 27552538 |
| miR34a | VAMP2 | Prolonged exposure of the beta-cell line MIN6B1 and pancreatic islets to palmitate causes a time- and dose-dependent increase of miR34a and miR146. Elevated levels of these miRNAs are also observed in islets of diabetic db/db mice.? | 18633110 |
| miR-34a | SIRT1 | Further, these findings suggest the therapeutic potential of targeting the novel miR-34a/NAMPT axis to treat SIRT1-related diseases of obesity and aging like liver steatosis and type 2 diabetes. | 23834033 |
| miR-34a-5p | EIF2AK3 | Conversely, silencing PERK alleviated stearic-acid-induced p53, miR-34a-5p and lipotoxicity. | 26969487 |
| miR375 | MTPN | Here we show that overexpression of miR-375 suppressed glucose-induced insulin secretion, and conversely, inhibition of endogenous miR-375 function enhanced insulin secretion. | 15538371 |
| miR-409 | NA | To unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated | 28776684 |
| miR-4284 | NA | Interestingly, we revealed a time and stage specific expression manner, as shown that expression of miR-4284 increased at the stage I of ASO and maintained the tendency to stage IV, while miR-4463 expression decreased at every stage of ASO; however, the expression of miR-4463 showed opposite change | 26370316 |
| miR-451 | p38 MAPK signalling, | The growth-inhibitory effect of miR-451 may be explained in part by miR-451-induced suppression of Ywhaz and p38 MAPK signalling,providing evidence for the potential role of miR-451 in early DN. | 21827757 |
| miR-454-3p | NA | miR-454-3p was overexpressed in both LBW and macrosomia (19.7-fold, p < 0.001 and 10.8-fold, p < 0.001, respectively), as compared to NBW. | 29182561 |
| miR-51 | GK | Through adenovirus mediated gain- and loss- of function study, we find that miR-451 negatively regulates hepatic gluconeogenesis and blood glucose levels in normal mice, and identify glycerol kinase (Gyk) as a direct target of miR-51. | 27495223 |
| miR-542 | NA | To unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated | 28776684 |
| miR-546 | NA | To unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated | 28776684 |
| miR-676 | NA | 1: Our approach revealed that expression of both the gene encoding ectodysplasin A (Eda), the causal gene in X-linked hypohidrotic ectodermal dysplasia (XLHED), and its intronic miRNA, miR-676, was increased in the livers of obese mice. 2. We also found that reducing miR-676 expression in db/db mice | 29770126, 29106399 |
| miR-6835-3p | NA | The results of the present study suggested that targeting AdipoR1 with miR?6835?3p inhibitors may be a potential strategy for promoting glucose?stimulated insulin secretion, and thereby, may be an effective treatment for type 2?DM. | 29916530 |
| miR7a | SNCA,CSPA | Furthermore, we found that miR-7a levels are decreased in obese/diabetic mouse models and human islets from obese and moderately diabetic individuals with compensated ? cell function. | 24789908 |
| miR-802 | HNF1B | Inducible transgenic overexpression of miR-802 in mice causes impaired glucose tolerance and attenuates insulin sensitivity, whereas reduction of miR-802 expression improves glucose tolerance and insulin action. | 23389544 |
| mir-9 | SIRT1 | This targeting is relevant in pancreatic ?-islets, where we show a reduction in Sirt1 protein levels when mir-9 expression is high during glucose-dependent insulin secretion. | 21288303 |
| miR-92a | PTBP1 | Despite the increase in PTBP1 protein in the pancreas of diabetic rats, we observed insulin expression to be reduced alongside upregulation of miR-25 and miR-92a, suggesting an intricate regulation of insulin (bio)synthesis at its mRNA level. | 24084692 |
| miR-96 | NA | Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are a | 22156553 |
| miR-99 | NA | While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with increased level of miR-122, miR-99 and decreased level of let-7d, miR-18a, miR-18b, miR-23a, | 29200427 |
| miRNA-29 | FTO,STAT3,DNMT1 | Via DNMT suppression, milk exosomal miRNA-29s may reduce the magnitude of FTO methylation, thereby epigenetically increasing FTO expression in the milk consumer.Notably, the galactopoietic hormone prolactin upregulates the transcription factor STAT3, which induces miRNA-29 expression. | 26691922 |
| miRNA33b/16 | INS | Plasma miRNA33b/16 levels revealed a positive correlation with plasma insulin level (r=0.326, P=0.021), serum C-peptide (r=0.280, P=0.049), and triglyceride (r=0.351, P=0.012), but no association with HDL-C (r=-0.210, P=0.143). | 27301461 |
| miRNA-378 | NA | MiRNA-378 was found to be significantly increased in db/db mice. PNPase as a contributor to mitochondrial miRNA import through the transport of miRNA-378, which may regulate bioenergetics during type 2 diabetes mellitus. | 28709769 |
| miRNA-463-3p | ABCG4 | Interestingly, in type 2 diabetes human pancreatic islets, expression of miRNA-463-3p and insulin was upregulated and ABCG4 downregulated compared with nondiabetic controls, and their expression levels were closely correlated. | 27664094 |
| miRNA-9-3p | SIRT1 | Therefore, these findings demonstrated that the inhibition of miRNA-9-3p reduced the proliferation of HepG2 cells and lipid accumulation by upregulating the expression of SIRT1, indicating its potential as a therapeutic target. | 26459099 |
