CCK
LOCUS ID885
GENE_SYMBOLCCK
GENE NAMEcholecystokinin
SYNONYMNS
CHROMOSOME3
HOMOLOGENE ID583
SOURCEMICE
PMIDs22357963
GENE SUMMARY
This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

OBSERVATION
1. These results suggest that CCK suppresses the activation of macrophage and expression of proinflammatory genes in diabetic kidney. Our findings may provide a novel strategy of therapy for the early stage of diabetic nephropathy.