| HDAC4 |
| LOCUS ID | 9759 | ||||
| GENE_SYMBOL | HDAC4 | ||||
| GENE NAME | histone deacetylase 4 | ||||
| SYNONYMNS | HD4 AHO3 BDMR HDACA HA6116 HDAC-4 HDAC-A | ||||
| CHROMOSOME | 2 | ||||
| HOMOLOGENE ID | 55946 | ||||
| SOURCE | MICE |
| PMIDs | 24578127 |
| GENE SUMMARY |
|---|
| Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008] |
| OBSERVATION |
|---|
| 1. hyperglycemia impairs miR-29a signaling to intensify HDAC4 actions that contribute to podocyte protein deacetylation and degradation as well as renal dysfunction. HDAC4, via epigenetic H3K9 hypoacetylation, reduces miR-29a transcription. The renoprotective effects of miR-29a in diabetes-induced loss of podocyte integrity and renal homeostasis highlights the importance of post-translational acetylation reactions in podocyte microenvironments. Increasing miR-29a action may protect against diabetic podocytopathy. |