| NAMPT |
| LOCUS ID | 10135 | ||||
| GENE_SYMBOL | NAMPT | ||||
| GENE NAME | nicotinamide phosphoribosyltransferase | ||||
| SYNONYMNS | VF PBEF PBEF1 VISFATIN 1110035O14Rik | ||||
| CHROMOSOME | 7 | ||||
| HOMOLOGENE ID | 4201 | ||||
| SOURCE | RAT |
| PMIDs | 24287278 |
| GENE SUMMARY |
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| This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011] |
| OBSERVATION |
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| 1. These data are consistent with a role of endogenous NAMPT activity as an adaptive, protective response to an inflammatory milieu that differs from the proinflammatory activity of exogenous NAMPT. Thus, disruption of endogenous NAMPT function in stressed cells promotes tubular cell death and chemokine expression. This information may be relevant for the design of novel therapeutic strategies in DN. |