| OSM |
| LOCUS ID | 5008 | ||||
| GENE_SYMBOL | OSM | ||||
| GENE NAME | oncostatin M | ||||
| SYNONYMNS | |||||
| CHROMOSOME | 22 | ||||
| HOMOLOGENE ID | 10741 | ||||
| SOURCE | MICE |
| PMIDs | 24217922 |
| GENE SUMMARY |
|---|
| Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008] |
| OBSERVATION |
|---|
| 1. OSM induced TEMT by activating the JAK/STAT pathway, which could be inhibited by SOCS. These results indicate that overexpression of SOCS has a therapeutic effect in DN. |