| PROC |
| LOCUS ID | 5624 | ||||
| GENE_SYMBOL | PROC | ||||
| GENE NAME | protein C (inactivator of coagulation factors Va a | ||||
| SYNONYMNS | PC, APC, PROC1, THPH3, THPH4 | ||||
| CHROMOSOME | 2 | ||||
| HOMOLOGENE ID | 37288 | ||||
| SOURCE | MICE |
| PMIDs | 23014597 |
| GENE SUMMARY |
|---|
| This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neotal purpura fulmins, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009] |
| OBSERVATION |
|---|
| 1. A protective effect of activated PC in diabetic nephropathy is established. |