| BDNF |
| LOCUS ID | 627 | ||||||
| GENE_SYMBOL | BDNF | ||||||
| GENE NAME | brain-derived neurotrophic factor | ||||||
| SYNONYMNS | ANON2 BULN2 | ||||||
| CHROMOSOME | 11 | ||||||
| HOMOLOGENE ID | 7245 | ||||||
| SOURCE | RAT |
| PMIDs | 22553539 | 20557422 | 20560879 |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009] |
| OBSERVATION |
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| 1. In the early stage of STZ diabetic, the administration of Ad.BDNF into the vitreous cavities can increase TH protein levels and the density of dopaminergic amacrine cells in the STZ rats' retina. 2. Increased BDNF activity in these neurons likely contributes to the reduction in Kv channel function through TrkB receptor stimulation in painful diabetic neuropathy. 3. This study suggests angelica injection has potential therapeutic effects on DPN, and the mechanism might be related to direct increase in NGF expression and direct or indirect increase in BDNF expression. |