| The canbinoid delta-9-tetrahydrocanbinol is the principal psychoactive ingredient of marijua. The proteins encoded by this gene and the canbinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for canbinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the canbinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijua. The canbinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008] |
