| IGF1 |
| LOCUS ID | 3479 | ||||||
| GENE_SYMBOL | IGF1 | ||||||
| GENE NAME | insulin-like growth factor 1 (somatomedin C) | ||||||
| SYNONYMNS | IGFI, IGF-I, IGF1A | ||||||
| CHROMOSOME | 12 | ||||||
| HOMOLOGENE ID | 515 | ||||||
| SOURCE | RAT |
| PMIDs | 21515376 |
| GENE SUMMARY |
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| The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] |
| OBSERVATION |
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| 1. during diabetes, the levels of insulin growth factor 1 (IGF1) decrease, reducing its neurotrophic effect in the brain, we also studied the effects of IGF1 treatment. The value of IGF1 in PDN treatment deserves further evaluation. |