| NFE2L2 |
| LOCUS ID | 4780 | ||||||
| GENE_SYMBOL | NFE2L2 | ||||||
| GENE NAME | nuclear factor, erythroid 2-like 2 | ||||||
| SYNONYMNS | NRF2, HEBP1 | ||||||
| CHROMOSOME | 2 | ||||||
| HOMOLOGENE ID | 2412 | ||||||
| SOURCE | MOUSE |
| PMIDs | 23569125 |
| GENE SUMMARY |
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| This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015] |
| OBSERVATION |
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| 1. The expression of Nfe2l2 and Hmox1 is downregulated in the sciatic nerve of diabetic animals compared with normal control animals.The NFE2L2 pathway has been implicated in diabetic neuropathy as a major regulator of antioxidant gene expression, including upregulation of the thioredoxin system. . Activation of NFE2L2 protects against oxidative stress in vitro and in vivo, and represents an important target for prophylaxis and treatment of diabetic complications. |